Beilstein J. Org. Chem.2011,7, 1584–1601, doi:10.3762/bjoc.7.187
in this article. Methodologies, selectivity, mechanism and future aspects are presented.
Keywords: ate complex; catalyticdirectarylation; mechanism; oxazole; selectivity; transition-metal catalysis; Introduction
Deprotonative metalation of aromatics is widely used as a powerful method for
]. Over the past decade, alternatives for more expeditive, practical and chemoselective arylating technics have arisen, thanks mainly to the great development of novel, stoichiometric and catalytic, directarylation methodologies (Scheme 1).
Thus novel classes of metallating agents resulting from various
group also occurred subsequently at the C5 position, exclusively producing the 2,4,5-triphenyloxazole. Fagnou then reported the direct C4-phenylation of 2,5-diphenyloxazole with phenylbromide by using a general catalysis that had proved to be useful in catalyticdirectarylation of azoles (Scheme 17
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Graphical Abstract
Scheme 1:
Stoichiometric and catalytic direct (hetero)arylation of arenes.